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PUBLISHED WORK

Literary Accomplishments

Last updated: 21-Aug-22

 

 

Full-length publications:​​

  1. Zhang J., Kwan H.L.R., Chan C.B. and Lee C.W. Localized release of muscle-generated BDNF regulates the initial formation of postsynaptic apparatus at neuromuscular synapses. Cell Death & Differentiation 2024 (in press)

  2. Tse M.C.L., Pang B.P.S., Bi X., Ooi T.X.C., Chan W.S. Zhang J., and Chan C.B. Estrogen regulates mitochondrial activity through inducing brain-derived neurotrophic factor expression in skeletal muscle. Journal of Cellular Physiology 2024 (In press) 

  3. Li C., Chan K.K., Nong W., Chen S., So W.L., Qu Z., Wu H.Y.C., Yip H.Y., Chan C.B., Tobe S.S., Bendena W.G., Kai Z.P., Hui  J.H.L. Insect metamorphosis is regulated differently between sexes by members of a microRNA cluster. 2024 eLife (in press)

  4. Pang B.P.S, Chan W.S., Tse M.C.L., Yeung C.T.Y., Wang M., Siu P.M., Lee C.W., Ye K., So H. and Chan C.B. Deficiency of BDNF in muscle causes inflammatory myopathy by inducing necroptosis and pyroptosis in skeletal muscle. Redox Biology 2024 78: 103418.

  5. Chan W.S., Ng C.F., Pang B.P.S., Tse M.C.L., Iu E.C.Y., Xin C.O., Yang X., Kim J.K., Lee C.W. and Chan C.B. Exercise-induced BDNF promotes peroxisome PPARδ-dependent reprogramming of lipid metabolism in skeletal muscle during exercise recovery. Science Signaling 2024 17: adh2783.

  6. Hang M., Tse M.C.L., Pang B.P.S., Bi X., Jin F., Lee C.W., Wong A.O.L. and Chan C.B. Differential regulation of hepatic SH3 domain binding kinase 1 (SBK1) expression in mouse and goldfish. General and Comparative Endocrinology 2023 344: 114372.

  7. Kwan H.L.R., Chan Z.C.K., Bi X., Kutkowska J., Proszynski T.J., Chan C.B. and Lee C.W. Nerve-Independent formation of membrane infoldings at topologically complex postsynaptic apparatus by caveolin-3 Science Advances 2023 9: eadg0183

  8. Kumar M., Duraisamy K., Annapureddy R.R., Chan C.B. and Chow B.K.C. Novel small-molecule MRGPRX2 antagonists inhibit the murine model of allergic reactions. Journal of Allergy and Clinical Immunology 2023 151: 1110-1122.

  9. Ahuja P.*, Bi X.*, Ng C.F., Tse M.C.L., Hang M., Pang B.P.S, Iu E.C.Y., Chan W.S., Ooi X.C., Sun A., Herlea-Pana O., Liu Z., Yang Y., Jiao B., Ma X., Wu K.K.L., Lee L.T.O., Cheng K.K.Y., Lee C.W. and Chan C.B. Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-fibroblast growth factor pathway. Hepatology 2023 77: 213-229.

  10. Yan R., Choi V.W.W., Hartono T., Tse I.M.Y., Tse M.C.L., Zhou Y., Xu J., Sit W.H., Wan J.M.F., Li E.T.S., Chan C.B. and Louie J.C.Y. Effect of lifelong sucrose consumption on food intake and body composition of C57BL/6N mice. Frontiers in Nutrition 2022 9: 1076073.

  11. Liu P., Wang Z., Kang S.S., Liu X., Chan C.B. and Ye K. High-fat Diet-induced Diabetes Couples to Alzheimer’s Disease through Inflammation-activated C/EBPβ/AEP Pathway. Molecular Psychiatry 2022 27: 3396-3409.

  12. Wang H., Xu H, Chen W., Cheng M., Zou L., Yang Q., Chan C.B., Zhu H., Chen C., Nie J. and Jiao B. Rab13 sustains breast cancer stem cells by supporting tumor-stroma crosstalk. Cancer Research 2022 82: 2121-2140.

  13. Law S.T.S., Nong W., So W.L., Baril T., Swale T., Chan C.B., Tobe S.S., Kai Z.P., Bendena W.G., Hayward A., and Hui J.H.L. Chromosomal-level reference genome of the moth Heortia vitessoides (Lepidotera: Crambidae), a major pest of agarwood-producing tree. Genomics 2022 114: 110440.

  14. Ahuja P.*, Ng C.F.*, Pang B.P.S.*, Chan W.S.*, Tse M.C.L., Bi X., Kwan H.L.R., Brobst D., Herlea-Pana O., Yang X., Du G., Saengnipanthkul S., Noh H.L., Jiao B., Kim J.K., Lee C.W., Ye K. and Chan C.B. Muscle-generated BDNF (brain-derived neurotrophic factor) maintains mitochondrial quality control in female mice. Autophagy 2022 18: 1367-1384

  15. Kundi Z.M., Lee J.C.Y., Pihlajamaki J., Chan C.B., Leung K.S., So S. S. Y., Kolehmainen M. and El-Nezami H. Oat and rye fibers ameliorate Western diet-induced body weight gain and hepatic inflammation in mice via modulation of short-chain fatty acid, bile acid, and tryptophan metabolism. Molecular Nutrition & Food Research 2020 e1900580

  16. Chan Z.C.K., Wong Y.S., He S., Chan C.B. and Lee C.W. Site-directed MT1-MMP surface insertion regulates neuromuscular synaptogenesis via focal ECM degradation. eLife 2020 9:e54379 

  17. Jia W., Wang N., Yin L., Chen X., Hou B., Wang J., Qiang G., Chan C.B., Yang X. and Du G. Effects of fasting on FGFs expression pattern in skeletal muscle phenotype and gender in mice. Biology of Sex Differences 2020 11:9

  18. Jiang X., He M., Bai J., Chan C.B. and Wong A.O.L. Signal transduction for TNFα-induced type II SOCS expression and its functional implication in growth hormone resistance in Carp hepatocytes. Frontiers in Endocrinology 2020 11:20. doi: 10.3389/fendo.2020.00020

  19. Bai J., He M., Chan C.B. and Wong A.O.L. Mechanisms for glucagon-induced IGF-I gene Expression in carp hepatocytes: signaling crosstalk to induce HNF1α and CREB expression for IGF-I promoter activation. Frontiers in Endocrinology 2019 10: 605.

  20. Yang X., Brobst D., Chan W.S., Tse M.C.L., Herlea-Pana O., Ahuja P., Bi X., Zaw A.M., Kwong Z.S.W., Jia W., Zhang Z., Zhang N., Chow S.K.H., Cheung W.H., Louie J.C.Y., Griffin T.M., Nong W., Hui J.H.L., Du G., Noh H.L., Saengnipanthkul S., Chow B.K.C., Kim J.K., Lee C.W. and Chan C.B. Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility Science Signaling 2019 12: eaau1468.

  21. Jia W., Wang N., Yin L., Chen X., Hou B., Qiang G., Chan C.B., Yang X., and Du G. Effect of skeletal muscle phenotype and gender on fasting-induced myokine expression in mice. Biochemical and Biophysical Research Communications 2019 514: 407-414.

  22. Chen T., Wong M.K.H., Chan C.B. and Wong A.O.L. Mechanisms for temperature modulation of feeding in Goldfish and implications on seasonal changes in feeding behavior and food intake. Frontiers in Endocrinology 2019 10: 133

  23. Zhang S., Sheng H., Zhang X., Qi Q., Chan C.B., Li L., Shan C. and Ye. K. Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation. Cell Death & Disease 2019 10: 222-234

  24. Yang X., Tse M.C.L., Hu X., Jia W., Du G., and Chan C.B. Interaction of CREB and PGC1α induces FNDC5 expression n C2C12 cells. Cellular Physiology and Biochemistry  2018 50: 1574-1584.

  25. Wood J., Tse M.C.L., Yang X., Brobst D., Liu Z., Pang B.P.S., Chan W.S., Zaw A.M., Chow B.K.C.C., Ye K., Lee C.W. and Chan C.B. BDNF Mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle. Metabolism 2018 87: 113-122

  26. Tse M.C.L, Herlea-Pana O., Brobst D., Yang X., Wood J., Hu X., Liu Z., Lee C.W., Zaw A.M., Chow B.K.C., Ye K. and Chan C.B.­ Tumor necrosis factor α promotes phosphoinositide 3-kinase enhancer A and AMP-activated protein kinase interaction to suppress lipid oxidation in skeletal muscle. Diabetes 2017 66: 1858-1870.

  27. Ma, S., Fang Z., Luo W., Yang Y., Wang C., Zhang Q., Wang H., Chen H., Chan C.B. and Liu Z. The C-ETS2-TFEB axis promotes neuron survival under oxidative stress by regulating lysosome activity. Oxidative Medicine and Cellular Longevity 2016: 4693703.

  28. Wang C, Zhao L., Su Q., Fan X., Wang Y., Gao S., Wang H., Chen H., Chan C.B. and Liu Z. Phosphorylation of MITF by Akt affects its downstream targets and causes TP53-dependent cell senescence. The International Journal of Biochemistry & Cell Biology 2016 80: 132-142.

  29. Zhang S., Qi Q., Chan C.B., Zhou W., Chen J., Appin C., Brat D.J. & Ye K. Fyn-phosphorylated PIKE-A Binds and Inhibits AMPK Signaling, Blocking its Tumor Suppressive Activity. Cell Death & Differentiation 2016 23: 52-63.

  30. Gross C., Chang C., Kelly S.M., Bhattacharya A., McBride S.M.J., Danielson S.W., Jiang M.Q., Chan C.B., Ye K., Gibson J.R., Klann E., Jongens T.A., Moberg K.H., Huber K.M.& Bassell G.J. 2015 Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in Fragile X syndrome. Cell Reports 2015 11: 727-736.

  31. Chan C.B., Tse M.C.L, Liu X., Zhang S., Schmidt R., Otten R., Liu L. & Ye K. Activation of Muscular TrkB by its Small Molecular Agonist 7,8-Dihydroxyflavone Sex-dependently Regulates Energy Metabolism in Diet-induced Obese Mice. Chemistry & Biology 2015 22: 355-369. (Featured article)

  32. Liu X., Obianyo O., Chan C. B., Huang J., Xue S., Yang J., Zheng F., Goodman M. & Ye K. Biochemical and biophysical investigation of brain-derived neurotrophic factor mimetic 7,8-Dihydroxyflavone in binding and activation of TrkB receptor. Journal of Biological Chemistry 2014 289: 27571-27584.

  33. Qiang G., Xue S., Yang J., Du G., Pang X., Li X., Goswami D., Griffin P., Ortlund E., Chan C.B.* & Ye K.* Identification of a small molecular insulin receptor agonist with potent anti-diabetic activity. Diabetes 2014 63: 1394-1409. (*: Corresponding authors)

  34. Chan C.B., Liu X., Zhao L., Liu G., Lee C.W., Feng Y. and Ye K. PIKE is essential for oligodendroglia development and CNS myelination. Proceedings of the National Academy of Sciences USA 2014 111: 1993-1998.

  35. Zhang Z., Liu X., Schroeder J., Chan C.B., Song M., Yu S.P., Weinshenker D. and Ye K. 7,8-Dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 2014 39: 638-650.

  36. He K., Qi Q., Chan C.B., Xiao G., Liu X., Tucker-Burden C., Wang L., Mao H., Lu X., McDonald F.E., Luo H., Fan Q., Weiss W.A., Sun S., Brat D.J. and Ye K. Blockade of glioma proliferation through allosteric inhibition of JAK2. Science Signaling 2013 6: ra55.

  37. Tse M.C.L., Liu X., Yang S., Ye K. and Chan C.B. Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction. Molecular and Cellular Biology 2013 33: 1797-1808.

  38. Hong Y., Chan C.B.*, Kwon I, Li X., Song M., Lee H., Liu X., Sompol P., Jin P., Lee H., Yu S.P. and Ye K.* SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer’s disease. The Journal of Neuroscience 2012 32: 17262-17272. (*Corresponding authors)

  39. Liu X., Chan C.B., Qi Q., Xiao G., Luo H.R., He X. and Ye K. Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression. Journal of Medicinal Chemistry 2012 55: 8524-8537.

  40. Chan C.B., Chen Y., Liu X., Papale L., Escayg A., Mei L. and Ye K.  Essential role of PIKE GTPases in neuronal protection against excitotoxic insults. Advances in Biological Regulation 2012 52: 66-76.

  41. Qi Q, He K., Yoo M.H., Chan C.B., Liu X., Zhang Z., Olson J.J., Xiao G., Wang L., Mao H., Tao H., Ramalingam S.S., Sun S.Y., Mischel P.S. and Ye K. Acridine yellow G is an orally bioactive agent for blocking glioblastoma growth via dual inhibition of EGFR and PKC kinases. The Journal of Biological Chemistry 2012 287: 6113-6127.

  42. He K.,Chan C.B.*, Liu X., Jia Y., Luo H.R., France S.A., Liu Y., Wilson W.D., and Ye K*. Identification of a small molecular activator for insulin receptor with potent anti-diabetic effects in mice. The Journal of Biological Chemistry 2011 286: 37379-37388. (* Corresponding authors)

  43. Chan C.B., Chen Y., Liu X., Tang X., Papale L., Escayg A., Mei L. and Ye K. PIKE-mediated PI 3-kinase activity is required for AMPA Receptor surface expression. The EMBO Journal 2011 30: 4274-4286.

  44. Chan C.B., Liu X., He K., Jung D.Y., Kim J.K. and Ye K. PIKE-A association with hepatic insulin receptor is essential for its physiological functions. EMBO Reports 2011 12: 847-854.

  45. Chan C.B., Liu X., Pradoldej S., Hao C., An J., Yepes M. and Ye K. Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex. The Journal of Neuroscience 2011 31: 8083-8092.

  46. Chan C.B., Liu X., Jung D.Y., Jun J.Y., Luo H.R., Kim J.K. and Ye K. Deficiency of PIKE protects mice from diet-induced obesity and insulin resistance. Diabetes 2010 59: 883-893.

  47. Chan C.B., Liu X., Ensslin M.A., Dillehay D.L. and Ye K. Requirement of PIKE-A for STAT5 activation in mammary gland development. The EMBO Journal 2010 29: 956-968.

  48. Liu X., Chan C.B., Pradoldej S., Jang S.W., Phun L.H., France S., Xiao G., Jia Y., Luo H.R. and Ye K. A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibit potent antidepressant effect. Journal of Medicinal Chemistry 2010 53: 8274-8286.

  49. Gross C., Nakamoto M., Yao X., Chan C.B., Yim S.Y., Ye K., Warren S.T., and Bassell G. Excess PI3K subunit synthesis and activity as a novel therapeutic target in Fragile X Syndrome. The Journal of Neuroscience 2010 30: 10624-10638.

  50. Jang S.W., Liu X., Chan C.B., France S., Sayeed I., Tang W., Lin X., Xiao G., Andero R., Chang Q., Ressler K.J. and Ye K. Deoxygedunin, a natural product with potent neurotrophic activity. PLoS ONE 2010 5: e11528

  51. Oh S.M., Liu Z., Okada M., Jang S.W., Liu X., Chan C.B., Luo H. and Ye K. Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity. Oncogene 2010 29:1017-1030.

  52. Chan C.B., Abe M., Hashimoto N., Hao C., Williams I.R., Liu X., Nakao S., Yamamoto Z, Zheng C., Henter J., Meeths M., Nordenskjold M., Li S., Hara-Nishimura I., Asano M., and Ye K. Mice lacking asparagine endopeptidase (AEP) develop disorders resembling hemophagocytic syndrome. Proceedings of the National Academy of Sciences USA 2009 106:468-473

  53. Chan C.B., Liu X., Jang S.W. Hsu S.I.H. and Ye K. NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association. Oncogene 2009 28: 3825-3836.

  54. Jang S.W., Liu X., Chan C.B., Weinshenker D., Hall R.A., Xiao G. and Ye K. Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chemistry & Biology 2009 16: 644-656.

  55. Lau P.N., Chow K.B.S., Chan C.B., Cheng C.H.K. and Wise H. The constitutive activity of the ghrelin receptor attenuates apoptosis via a protein kinase C-dependent pathway. Molecular and Cellular Endocrinology 2009 299: 232-239.

  56. Jiao B., Yeung E.K.C., Chan C.B. and Cheng C.H.K. Establishment of a transgenic yeast screening system for estrogenicity and identification of the anti-estrogenic activity of malachite green. Journal of Cellular Biochemistry 2008 105:1399-1409.

  57. Tang X., Jang S.W., Okada M., Chan C.B., Feng Y, Liu Y., Luo S.W., Hong Y., Rama N., Xiong, W.C. and Ye K. Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B. Nature Cell Biology 2008 10:698-706.

  58. Chan C.B., Liu X., Tang X., Fu H. and Ye K. 2007 Akt phosphorylation of zyxin mediates its interaction with acinus-S and prevents acinus-triggered chromatin condensation. Cell Death and Differentiation 2007 14: 1688-1699.

  59. Chan C.B., Tang W.K., Cheng C.H.K and Fong W.P. Cloning of the black seabream (Acanthopagrus schlegeli) antiquitin gene and functional characterization of its promoter region. Molecular and Cellular Biochemistry 2007 297: 151-160.

  60. Wang X., Yue P., Chan C.B., Ye K., Ueda T., Watanabe-Fukunaga R., Fukunaga R., Fu H., Khuri F.R. and Sun S.Y. Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3 kinase-dependent and Mnk-mediated eIF4E phosphorylation. Molecular and Cellular Biology 2007 27:7405-7413.

  61. Huang X., Jiao B., Fung C.K., Ho W.K.K., Zhang Y., Chan C.B., Lin H., Wang D. and Cheng C.H.K.  The presence of two distinct prolactin receptors in seabream with different tissue distribution patterns, signal transduction pathways and regulation of gene expression by steroid hormones. Journal of Endocrinology 2007 194: 373-392.

  62. Leung P.K., Chow K.B.S., Lau P.N., Chu K.M., Chan C.B., Cheng C.H.K. and Wise H The truncated ghrelin receptor peptide (GHSR-1b) acts as a dominant-negative mutant of the ghrelin receptor. Cellular Signaling 2007 19: 1011-1022.

  63. Chu K.M., Chow K.B.S., Leung P.K., Lau P.N., Chan C.B., Cheng C.H.K. and Wise H. Over-expression of the truncated ghrelin receptor polypeptide attenuates the constitutive activation of phosphatidylinositol-specific phospholipase C by ghrelin receptors but has no effect on ghrelin-stimulated extracellular signal-regulated kinase 1/2 activity. International Journal of Biochemistry and Cell Biology 2007 39: 752-764.

  64. Yeung C.M., Chan C.B., Woo N.Y.S. and Cheng C.H.K.The seabream ghrelin: cDNA cloning, genomic organization and promoter studies. Journal of Endocrinology 2006 189:365-379.

  65. Jiao B., Huang X., Chan C.B., Zhang L., Wang D. and Cheng C.H.K. The co-existence of two growth hormone receptors in teleost fish and their differential signal transduction, tissue distribution and hormonal regulation of expression in seabream. Journal of Molecular Endocrinology 2006 36:23-40.

  66. Tang W.K., Chan C.B., Cheng C.H.K. and Fong W.P. Seabream antiquitin: molecular cloning, tissue distribution, subcellular localization and functional expression. FEBS Letters 2005 579:3759-3764.

  67. Chan C.B., Fung W., Tse M.C.L., Fung C.K. and Cheng C.H.K.Stimulation of growth hormone secretion from seabream pituitary cells in primary culture by growth hormone secretagogues is independent of growth hormone transcription. Comparative Biochemistry and Physiology Part C Toxicology and Pharmacology 2004 39:77-85.

  68. Chan C.B., Leung C.P.K., Wise H. and Cheng C.H.K. Signal transduction mechanism of the seabream growth hormone secretagogue receptor. FEBS Letters 2004 577:147-153.

  69. Chan C.B. and Cheng C.H.K. 2004 Identification and functional characterization of two alternatively spliced growth hormone secretagogue receptor transcripts from the pituitary of black seabream Acanthopagrus schlegeli. Molecular and Cellular Endocrinology 2004 214:81-95.

  70. Yeung C.M., Chan C.B. and Cheng C.H.K. Isolation and characterization of the 5’-flanking region of the growth hormone secretagogue receptor gene from black seabream Acanthopagrus schlegeli. Molecular and Cellular Endocrinology 2004 223:5-15.

  71. Tse D.L.Y., Tse M.C.L., Chan C.B., Deng L., Zhang W.M., Hiu H.R. and Cheng C.H.K. Seabream growth hormone receptor: molecular cloning and functional studies of the full-length cDNA, and tissue distribution of two alternatively spliced forms. Biochimica et Biophysica Acta 2003 1625:64-76.

  72. Tse D.L.Y., Chow B.K.C., Chan C.B., Lee L.T.O. and Cheng C.H.K. Molecular cloning and expression studies of a prolactin receptor in goldfish (Carassius auratus). Life Sciences 2000 66: 593-605.

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Invited reviews and book chapters:

  1. Iu E.C.Y., Ho S. and Chan C.B. Mitochondrial defects in sporadic inclusion body myositis – cause and consequences Frontier in Cell and Developmental Biology 2024 12: fcell.2024.1403463 

  2. Iu E. C. Y. and Chan C.B. Is brain-derived neurotrophic factor a metabolic hormone in peripheral tissues? Biology (Basel) 2022 11: 1063.

  3. Yan R., Chan C.B. and Louie J.C.Y. Current World Health Organization recommendation to reduce free sugar intake from all sources to below 10% of daily energy intake for supporting cardiometabolic health is not well-supported by available evidence. The American Journal of Clinical Nutrition 2022 116: 15-39.

  4. Pang B.P.S., Chan W.S. and Chan C.B. Mitochondrial homeostasis and oxidant/anti-oxidant balance in skeletal muscle – do myokines play a role? Antioxidant 2021 10: 179.

  5. Chan C.B.*, Ahuja P. and Ye K. Developing insulin and BDNF mimetics for diabetes therapy. Current Trends in Medicinal Chemistry 2019 19: 2188-2204. (*: corresponding author)

  6. Chan C.B. and Ye K Sex Differences in Brain-Derived Neurotrophic Factor Signaling and Functions Journal of Neuroscience Research 2017 95: 328-335.

  7. Liu C., Chan C.B. & Ye K. 7,8-Dihydroxyflavone, a small molecular TrkB Agonist, useful for treating various BDNF-implicated human disorders. Translational Neurodegeneration 2016 5: 2-10.

  8. Chan C.B.* and Ye K. Serine-arginine protein kinases: new players in neurodegenerative diseases? Reviews in the Neurosciences 2013 24: 401-413. (*: Corresponding author)

  9. Chan C.B. and Ye K. SRPK2 activity and Alzheimer’s dementia. Cognitive Sciences 2012 7: 1-23.

  10. Chan C.B.* and Ye K. PIKE in the brain: Is it simply a phosphoinositide 3-kinase/Akt enhancer? Reviews in the Neurosciences 2012 23: 153-161. (*: Corresponding author)

  11. Chan C.B. and Ye K. What we have learnt about PIKE from the knockout mice. International Journal of Biochemistry and Molecular Biology 2011 2: 228-239.

  12. Chan C.B. and Ye K. Nuclear Akt: an important kinase in an inconspicuous compartment. Trends in Cell & Molecular Biology 2010 5: 35-48.

  13. Chan C.B. and Ye. K. Multiple functions of phosphoinositide-3 kinase enhancer. TheScientificWorldJOURNAL 2010 10:613-623.

  14. Chan C.B. and Ye K. CENTG1 (Centaurin, gamma1). Atlas of Genetics and Cytogenetics in Oncology and Haematology 2007 11: 52-54.

  15. Chan C.B. and Ye K. PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death. Journal of Cellular and Molecular Medicine 11:39-53.

  16. Yeung C.M., Chan C.B. & Cheng C.H.K. Cells of the anterior pituitary. International Journal of Biochemistry and Cell Biology 2006 38: 1441-1449.

  17. Chan C.B., Tse M.C.L. & Cheng C.H.K. Regulation and mechanism of growth hormone and insulin-like growth factor-I biosynthesis and secretion. p3-19 In “The somatotrophic axis in brain function” 2005 Nyberg F. eds. Elsevier Academic Press, San Diego, CA, USA.

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